The church was rebuilt in 1716 on the foundation of the old church. When the Spanish returned to New Mexico after the Pueblo Indian Revolt of 1680, they found the church destroyed, except for the nave. It is one of the oldest mission churches in the United States. The Spanish Mission of San Agustín de la Isleta was built in the Pueblo in 1612 by Spanish Catholic Franciscans.
The name Isleta is Spanish for 'little island'.
